B cell precursor acute lymphoblastic leukemia, pediatric, WT1 transcript levels, clinical characteristics, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

IntroductionThe prognostic role of Wilms’ tumor 1 (WT1) gene expression at diagnosis in children with B cell precursor acute lymphoblastic leukemia (BCP-ALL) is still controversial.MethodsWe detected the WT1 transcript levels of 533 de novo pediatric BCP-ALL patients using TaqMan-based real-time quantitative PCR and analyzed their clinical features.ResultsThe WT1 transcript levels differed among the distinct molecularly defined groups, with the highest levels in the KMT2A rearrangements (KMT2A-r) group. According to the results of the X-tile software, all patients were divided into two groups: WT1/ABL ≥ 0.24% (group A) and