постменопаузальный остеопороз, кальцитонин, генетический полиморфизм, Osteopathy, RZ301-397.5

Postmenopausal osteoporosis is a widespread complex disease with strong genetic predisposition. The aim of this study was to fnd association of (CA)n polymorphism of calcitonin gene (CALCA) with the risk of postmenopausal osteoporosis and serum calcitonin level in Russian women from Volga-Ural region. DNA samples of 372 women aged from 48 to 77 years old (175 with fractures and 197 without fractures) were used in the study. Femoral neck BMD was measured in 185 women, lumbal spine BMD - in 203 women. The serum calcitonin was measured in 168 women. Eight alleles of (CA)n polymorphism were revealed: each allele contained 10, 11, 12, 15, 16, 17, 18 and 19 CA repeats. CALCA*10*10 genotype is a marker of the decreased risk of osteoporosis (OR = 0,21) and osteopenia (OR = 0,21). CALCA*10*10 and CALCA*17*17 genotypes were shown to be associated with high femoral neck BMD. Statistically signifcant association of CALCA*17 allele with the increased calcitonin level have been shown.