Abstract Professionals like deep-miners and factory-workers wear specialized safety-shoes to protect against occupational hazards (OF). The risk factors, clinico-microbiologic profile and complications of diabetic foot ulcers (DFU) in these professionals remain unexplored. A cross-sectional observational study was conducted to describe the unique clinico-microbiologic profile of DFU in those wearing occupational-footwear (OF) and find risk factors for DFU related osteomyelitis in them. Of 331 DFU cases seen over 5 years, those wearing OF (n = 107, 68 underground-miners and 39 steel-factory-workers) had high prevalence of forefoot-DFU (81.3%), dorsal-DFU ( 58.9%), recurrent-DFU (31.8%) and of polymicrobial infections (16.8%). Those with osteomyelitis in the OF group ( n = 53) were younger (53.3 vs. 57, p = 0.02), had higher prevalence of peripheral arterial disease (41.5% vs. 24.1%), past-amputation (28.3% vs. 11.1%), higher SINBAD scores, and were also less likely to change occupational-footwear at