системная красная волчанка, аутоантитела, лабораторные нарушения, мониторинг больных системной красной волчанкой., Medicine

Laboratory examination is an integral part of managing patients with systemic lupus erythematosus (SLE). A number of laboratory tests need to be conducted to verify the diagnosis; some indicators attest to the development of a concomitant pathology (development of comorbid conditions and therapeutic aggravation). The monitoring of individual laboratory tests makes it possible to assess the effectiveness of therapy or indicates that it needs to be enhanced in some cases. Furthermore, some parameters are considered to be prognostic factors of treatment outcome. The article reports on the range and frequency of laboratory errors in SLE patients. The role of laboratory tests in diagnosis and assessment of disease prognosis is discussed. The relationship between clinical and laboratory manifestations and the mechanisms for preventing laboratory errors are studied. The international guidelines for monitoring SLE patients are presented. Proper range of examination of SLE patients and interpretation of the results ensures timely diagnosis (sometimes at the early stage) and allows one to avoid a hyperdiagnosis, to timely prescribe adequate therapy, and prevent its complications.