Alzheimer's Disease, PET/MR, ALPS-index, Early-phase Aβ imaging, Cerebral perfusion, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

Early-phase Aβ imaging can detect cerebral perfusion deficits, while glymphatic dysfunction is a key event in neurodegenerative diseases, including Alzheimer's disease (AD). However, their relationship within the AD continuum remains unclear. This study aimed to evaluate the role of the glymphatic system (diffusion tensor image analysis along the perivascular space, DTI-ALPS) and early-phase Aβ imaging in cognitive impairment using simultaneous PET/MR in healthy control (HC), Prodromal AD (PAD), and AD. It also examines the interaction between baseline amyloid (Aβ) burden and vascular burden in perfusion impairment and glymphatic dysfunction. AD patients showed lower SUVr of early-phase Aβ in the bilateral hippocampus, parahippocampal, and caudate (all P