The insect growth regulator (IGR) methoprene is labeled in the United States (US) for direct application to stored grain commodities, and as a residual surface treatment to empty grain bins and flooring surfaces inside indoor structures. Methoprene is also labeled in the US as an aerosol for use in indoor areas. One of the challenges in research with methoprene and stored product insects is through design of experiments that mimic how methoprene would be used in practical applications. Recent research with methoprene will be used to describe experimental designs to examine efficacy of methoprene when used as a grain protectant.