Acute compartment syndrome, Amputation, Crush injury, Fracture, Nomogram prediction model, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

Abstract Purposes Amputation is a serious complication in patients with acute compartment syndrome (ACS). However, it risk factors are still poorly understood. Our study aims to investigate the risk factors of amputation in patients with ACS. Methods We reviewed the data on ACS patients with tibial fractures from January 2010 to November 2022. Patients with amputation was grouped into the amputation group (AG) and those without amputation was grouped into non-amputation group (NG). We used univariate analysis, logistic regression analysis and nomogram prediction model to analyze the predictors of amputation. Results The rate of amputation was 8.8% (12 of 136) in our study. Crush injury (p = 0.047), heavy object injury (p = 0.045), the presence of blisters (p