Obstructive sleep apnea hypopnea syndrome, Pollinosis, NHANES, Association analysis, Risk stratification analysis, Diseases of the respiratory system, RC705-779

Abstract Background Rhinobyon and inflammation associated with pollinosis may elevate the risk of obstructive sleep apnea hypopnea syndrome (OSAHS). However, the exact nature of this association remains unclear, particularly in large-scale populations. This study aimed to examine the relationship between pollinosis and OSAHS using data from the National Health and Nutrition Examination Survey (NHANES). Methods Data from the NHANES spanning 2005 to 2018 were analyzed. Three multivariate generalized linear models (GLMs) were employed to explore the relationship between pollinosis and OSAHS: one unadjusted model, one minimally adjusted model, and one fully adjusted model. Stratified analyses were conducted to assess the impact of pollinosis and other covariates on OSAHS. Additionally, the study incorporated K-Nearest Neighbors (KNN) and smoothed curves to refine the analysis. Results The study identified significant demographic differences between groups in factors such as pollinosis, age, gender, weight (WT), body mass index (BMI), waist circumference (WC), protein, and fat. In three adjusted models, a consistent association was observed between pollinosis and OSAHS. Specifically, Model 1 showed an odds ratio (OR) of 1.31 [95% confidence interval (CI): 1.16–1.48, P