Construction of a dynamic nomogram to predict osteoporosis in elderly maintenance hemodialysis patients based on microinflammatory indicators

2025

Linchuang shenzangbing zazhi, Vol 25, Iss 4, Pp 319-326 (2025)

ObjectiveTo construct a dynamic nomogram （DynNom） to predict osteoporosis in elderly maintenance hemodialysis patients based on the microinflammatory indicators of high-sensitivity C reactive protein （hs-CRP） and procalcitonin （PCT）.MethodsElderly maintenance hemodialysis patients admitted to Nanjing Lishui People's Hospital （Zhongda Hospital Lishui Branch， Southeast University） from January 1， 2020 to January 31， 2023 and from February 1 to April 30， 2023 were selected and enrolled in the training set （n=161） and validation set （n=37）. Patients in the training set were divided into the osteoporosis group （n=71） and non-osteoporosis group （n=90） according to the occurrence of osteoporosis. Clinical data of the patients were collected. Univariate and multivariate regression analyses were performed to identify factors affecting osteoporosis in elderly patients with maintenance dialysis. The values of hs-CRP and PCT in predicting osteoporosis in elderly maintenance hemodialysis patients were assessed using receiver operating characteristic （ROC） curves， and the DynNom was established accordingly.ResultsThere were no significant differences in the gender， age， smoking history， primary disease， duration of chronic renal failure， blood calcium， blood phosphorus， blood potassium， whole segment parathyroid hormone， creatinine， uric acid， and alkaline phosphatase between the osteoporosis group and non-osteoporosis group （P>0.05）. The percentage of patients in the osteoporosis group with body mass index （BMI）

article

Chinese

Editorial Department of Journal of Clinical Nephrology, 2025.

high-sensitivity c reactive protein, calcitoninogen, dialysis, osteoporosis, dynamic nomogram, Internal medicine, RC31-1245