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Academic Journal
OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY
M. V. Shirayeva, Yu. G. Kirillova, E. D. Nikol’Skaya, D. I. Prokhorov, I. P. Smirnov, G. E. Pozmogova
Тонкие химические технологии, Vol 8, Iss 1, Pp 87-95 (2013)
Sparad:
| Titel | OPTIMIZATION OF SOLID-PHASE SYNTHESIS OF POLYAMIDE NUCLEIC ACID MIMETICS WITH APPLICATION OF MALDI-TOF MASS-SPECTROMETRY |
|---|---|
| Författarna | M. V. Shirayeva, Yu. G. Kirillova, E. D. Nikol’Skaya, D. I. Prokhorov, I. P. Smirnov, G. E. Pozmogova |
| Utgivningsår |
2013
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| Källa |
Тонкие химические технологии, Vol 8, Iss 1, Pp 87-95 (2013)
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| Beskrivning |
The solid-phase synthesis of a tetrameric model sequence of polyamide nucleic acid mimetics (PANAM) incorporating terminal chiral and charged unit was performed. As a result during the synthesis and cleavage from the resin the tendency of PANAM with the N-terminal negatively charged monomer to cyclization with simultaneous N-acyl transfer of carboxyethyl base residue was found. Application of MALDI-TOF mass - spectrometry allowed us to find suitable conditions for obtaining PANAM oligomers without the significant amount of by-products.
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| Dokumenttyp |
article
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| Språk |
Russian
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| Information om utgivare |
MIREA - Russian Technological University, 2013.
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| Ämnestermer | |
