dietary index for gut microbiota, cardiometabolic multimorbidity, systemic immune-inflammation index, systemic inflammatory response index, NHANES, Nutrition. Foods and food supply, TX341-641

ObjectiveThis study targets to investigate the connection between the possibility of Cardiometabolic Multimorbidity (CMM) and the Dietary Index for Gut Microbiota (DI-GM), paying special attention to the mediating roles of systemic inflammatory markers, specifically the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammatory Response Index (SIRI).MethodsA cross-sectional study was conducted involving 17,388 eligible participants from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2020. Weighted logistic regression model was employed to assess the correlation between DI-GM, SII, SIRI, and CMM. Additionally, restricted cubic spline (RCS) regression model was utilized to investigate any potential nonlinear relationships between these variables and the risk of CMM. The degree to which SII and SIRI mediated the link between CMM and DI-GM was assessed using mediation analysis. Additionally, sensitivity and subgroup analyses were conducted to confirm the results.ResultsA lower risk of CMM was markedly correlated with higher DI-GM scores (OR = 0.94, 95% CI: 0.91–0.98, p = 0.001). An elevated risk of CMM was markedly linked to higher levels of Ln-SII and Ln-SIRI (OR = 1.45, 95% CI: 1.28–1.65, p