Bacteria resistant to most or all of the known antibiotics have been causing more serious problems recently, thus increasing the risk of return of the medical community to the times when antibiotics not yet emerged, and incurable infections and epidemics were widespread. Despite the active work of the leading global chemical and pharmaceutical specialists, over the past 30 years synthesis of new classes of antibiotics has dramatically decreased.The emergence of fundamentally new antibacterial agents in the clinical practice.is not going to happen any time soon. Some hope that the new method of complete sequencing of microbial genomes and determining the molecular basis of pathogenicity will open up new ways of treatment of infectious diseases, though greater effort is applied to search for other approaches.