Parkinson's disease, Middle-aged and elderly populations, Global burden of disease, Socio-demographic index, Epidemiological trends, Neurology. Diseases of the nervous system, RC346-429

Abstract Background Parkinson’s disease (PD) has emerged as a major global public health challenge. However, there is currently a lack of systematic analysis regarding the burden of PD and its long-term trends among people over 55 years of age. Methods This study utilizes data from the Global Burden of Disease 2021 database to analyze the prevalence, incidence, disability-adjusted life years (DALYs), and mortality rates of PD in individuals aged 55 and older from 1990 to 2021. The annual percentage change was calculated to assess the temporal trends of the disease burden. Point estimates and their corresponding ranges were reported with 95% uncertainty intervals. Results Globally, the prevalence, incidence, DALYs, and mortality rates of PD in individuals aged 55 and above significantly increased from 1990 to 2021, with all indicators being higher in males than in females. This trend was evident across all five Socio-Demographic Index (SDI) groups and in 21 regions worldwide. The number of prevalent cases, incident cases, DALYs, and deaths all showed significant increases and were positively correlated with SDI (R = 0.645, P