Coronary heart disease, Revascularization, Swept source optical coherence tomography angiography, Gensini score, Retinal microvascular, Medicine, Science

Abstract This study aimed to quantify fundus microvascular alterations in patients requiring revascularization for coronary heart disease (CHD) using swept-source optical coherence tomography angiography (SS-OCTA) and to investigate the correlation between these alterations and the severity of coronary artery lesions. SS-OCTA was employed to assess the fundus neurovascular parameters of all participants, while the Gensini score was utilized to gauge the severity of coronary artery lesions in observation group. A total of 98 participants (49 CHD patients and 49 controls) were included. Analysis of the SS-OCTA parameters revealed that the vascular density (VD) of the superficial vascular plexus (SVP), the superficial vascular complex (SVC), the intermediate capillary plexus (ICP) in the parafoveal region, the mean ICP in the macula, deep capillary plexus (DCP) and deep vascular complex (DVC) in each macular region were significantly reduced in the observation group compared to the control group (P