Accessibility is a crucial indicator for evaluating the spatial rationalization of commercial facilities in an area, impacting both commercial development and service efficiency. The objective of this research is to analyze the commercial space layout of Maotai Town in Guizhou Province, China, and to design an evaluation system for commercial space accessibility to enhance the efficiency of commercial space use. Firstly, POI (Point of Interest) Data Visualization Analysis will be employed to identify major commercial hotspots and areas not covered by their service reach. Secondly, the spatial accessibility of commercial spaces will be evaluated using Space Syntax and the Cost-Weighted Model in the topological grid dimension and geometric grid dimension. Finally, we will establish a Minimum Cumulative Resistance Model (MCR Model) based on the analysis results obtained to identify the resistance paths that tourists navigate within the research area. This method will provide a precise framework for evaluating the accessibility of commercial spaces throughout the area.