acute myocardial infarction, all‐cause mortality, cardiac death, eosinophil, hospital discharge, Diseases of the circulatory (Cardiovascular) system, RC666-701

Background Preclinical studies demonstrate a cardioprotective role of eosinophils in acute myocardial infarction. Yet clinical studies show conflicting correlations between blood eosinophil counts and acute myocardial infarction risk and mortality. This study evaluates blood eosinophil counts of patients with acute myocardial infarction at hospital admission (EOSbaseline) and discharge (EOSpost) on all‐cause and cardiac mortalities. Methods and Results Of 2681 consecutive patients with a median follow‐up of 2.55 years, 45 patients died within 30 days, 28 died within 30 to 150 days, and 92 died within 150 days or later postdischarge. Cardiac death occurred in 108 patients. According to the receiver operating characteristic analyses, the best cutoffs of EOSbaseline and EOSpost were 0.02×109/L and 0.03×109/L, respectively, to predict 30‐day all‐cause death (area under the curve [AUC]baseline, 0.60; AUCpost, 0.67). The optimal cutoffs of EOSbaseline and EOSpost were 0.20×109/L and 0.14×109/L to predict long‐term all‐cause mortality (1‐year AUCbaseline, 0.59; 1‐year AUCpost, 0.61). Multivariate logistic analysis showed that low EOSbaseline (