Abstract : This study aims to investigate the association between self-efficacy proficiency and general adaptation dimensions among extremity-amputee diabetics. Employing a descriptive correlational methodology, a sample of 54 participants was drawn from the internal medicine department. The assessment tools used in the study included Ralf Schwarzar's self-efficacy scale and a researcher-designed general adaptation scale. The statistical analysis revealed a statistically significant correlation between self-efficacy proficiency and the general level of adaptation, encompassing psychological, social, and health-related domains. Furthermore, the findings underscored the absence of any substantial gender-based discrepancies pertaining to self-efficacy proficiency. However, noteworthy distinctions in self-efficacy proficiency were observed. Keywords : Self-efficacy; General adaptation; psychological adaptation; social adaptation; health adaptation; extremity-amputee diabetics.