Objective: Recent studies showed that Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI) can be used as inflammatory markers. The aim of this study was to determine the prognostic value of SII and SIRI in children with Bell’s palsy (BP) disease. Method: This retrospective study included 107 children diagnosed with BP from 2019 to 2022 in institute and an age- and sex-matched 100 healthy control group. A complete blood count was performed for all participants and hemoglobin, erythrocytes, white blood cell (WBC), absolute neutrophil count (ANC), lymphocytes, and platelet counts were measured. The platelet-lymphocyte ratio, neutrophil-to-lymphocyte ratio (NLR), SII and SIRI values were calculated with the formula. Results: The male-to-female ratio was 54/53 in patient and 42/58 in the control groups. In estimation of BP, area under the curve was 0.78 for WBC [95% confidence interval (CI): 0.72-0.84, p