Determination of 36 Veterinary Drug Residues in Cooked Meat by Ultra Performance Liquid Chromatography-tandem Mass Spectrometry

2023

Shipin gongye ke-ji, Vol 44, Iss 13, Pp 340-348 (2023)

A method was developed for the determination of amantadine sulfonamides, quinolones and chloramphenicols in cooked meat. The samples were extracted with acetonitrile-water mixtures (V:V=8:2), purified with PRiME HLB solid phase extraction column. 36 veterinary drugs were determined by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) with an electrospray ion source (ESI±) in positive and negative ion switching scanning mode. The results showed that the 36 veterinary drugs showed a good linear relationship in the concentration range of 0.5~20.0 ng/mL (R2>0.999). The limits of detection were 0.10 μg/kg and the limits of quantitation were 0.33 μg/kg. The average recovery was 70.8%~106.9% in the range of high, medium and low concentrations (0.5, 1.0 and 5.0 μg/kg). The relative standard deviations (RSD, n=6) was 0.2%~6.2%. The method is simple, sensitive and accurate, and could be used for the determination of 36 veterinary drug residues in cooked meat.

article

Chinese

The editorial department of Science and Technology of Food Industry, 2023.

ultra performance liquid chromatography-tandem mass spectrometry, cooked meat, prime hlb solid phase extraction, veterinary drug residue, Food processing and manufacture, TP368-456