gnn, superpixel metric learning, memory efficient model, white blood cell segmentation, cell type classification, Biotechnology, TP248.13-248.65, Mathematics, QA1-939

An automatic recognizing system of white blood cells can assist hematologists in the diagnosis of many diseases, where accuracy and efficiency are paramount for computer-based systems. In this paper, we presented a new image processing system to recognize the five types of white blood cells in peripheral blood with marked improvement in efficiency when juxtaposed against mainstream methods. The prevailing deep learning segmentation solutions often utilize millions of parameters to extract high-level image features and neglect the incorporation of prior domain knowledge, which consequently consumes substantial computational resources and increases the risk of overfitting, especially when limited medical image samples are available for training. To address these challenges, we proposed a novel memory-efficient strategy that exploits graph structures derived from the images. Specifically, we introduced a lightweight superpixel-based graph neural network (GNN) and broke new ground by introducing superpixel metric learning to segment nucleus and cytoplasm. Remarkably, our proposed segmentation model superpixel metric graph neural network (SMGNN) achieved state of the art segmentation performance while utilizing at most 10000X less than the parameters compared to existing approaches. The subsequent segmentation-based cell type classification processes showed satisfactory results that such automatic recognizing algorithms are accurate and efficient to execeute in hematological laboratories. Our code is publicly available at Visa.