DVT, lncRNA ADB16-AS1, Inflammatory response, Oxidative stress, Occurrence, Development, Diseases of the circulatory (Cardiovascular) system, RC666-701

Abstract Background Deep venous thrombosis (DVT) is a kind of vascular obstruction, that commonly and widely occurs in lower limbs. Due to the lack of obvious symptoms in the early stage, the rate of misdiagnosis and missed diagnosis is high. This study evaluated the expression and significance of lncRNA ASB16-AS1 (ASB16-AS1) in DVT aiming to identify a novel biomarker for its screening and monitoring. Methods There were 77 DVT patients and 62 healthy individuals included in this study. Plasma ASB16-AS1 level was evaluated using PCR and compared between DVT and healthy groups. The diagnostic and prognostic values of ASB16-AS1 were assessed with ROC and Cox analyses. The correlation of ASB16-AS1 with patients’ conditions, inflammation, and oxidative stress was evaluated by Spearman correlation analysis. Results ASB16-AS1 was significantly upregulated in DVT (P