атопический дерматит, псориаз, склеродермия, хроническая крапивница, цитокины, «кожное окно», актг, Medicine

Research subject. In the in-patient therapeutic unit, 94 persons, females and males, aged 18-45 were examined. There were 19 patients with atopic dermatitis, 24 with scleroderma, 26 with chronic urticaria, and 25 with psoriasis. The control group included 25 healthy volunteers at the age of 20-35 years old. The aim of the research was to determine the values of adrenocorticotropic hormone (ACTH) in a cell-free fraction of «skin window» exudate in patients with these immune system-mediated pathological conditions of the skin and healthy individuals. Material and methods. The material for investigation of ACTH values was a cell-free fraction of «skin window» exudate obtained from a 1 mL chamber placed on the scarified area, pre-filled with sterile 0.9 % sodium chloride solution according to the certified medical technology. Determination of ACTH values were carried out using electrochemiluminescence immunoassay method. Results. The patients with skin pathologies displayed a reliable decrease of ACTH values in skin exudates in comparison with the control group that may contribute to pathogenesis of these diseases in a significant manner. Conclusions. The decreased level of ACTH in skin exudates in atopic dermatitis, psoriasis, scleroderma, and chronic urticaria suggests impaired endocrine influence on skin cells, including SALT, thereby reducing anti-inflammatory potential of the skin and increasing pro-inflammatory activity in it.