fingolimod, multifocal electroretinogram, pattern electroretinogram, optical coherence tomography, elapsing–remitting multiple sclerosis, Ophthalmology, RE1-994

Objective To detect the role of pattern electroretinogram (PERG) and multifocal electroretinogram (MfERG) for macular function evaluation in patients with relapsing–remitting multiple sclerosis (RR-MS) treated by fingolimod. Patients and methods This prospective research was carried out on 25 patients with RR-MS (50 eyes), treated by fingolimod, with no ophthalmic disorders or complaints before the onset of the treatment, including no history of optic neuritis. PERG, MfERG, and spectral domain optical coherence tomography were performed before then 3 and 6 months after the treatment. Results Best-corrected visual acuity (BCVA) significantly decreased in third and sixth months compared to baseline (P