aflatoxin b1, high-fat diet, lipid metabolism, gut-liver axis, gut microbiota, bifidobacterium breve, Nutrition. Foods and food supply, TX341-641

Aflatoxin B1 (AFB1) is a common contaminant in cereals of global concern, and long-term low-dose exposure can adversely affect human health. Here, we showed that populations with dietary patterns characterized by high-fat diet (HFD) might have an increased risk of exposure to high levels of AFB1. Our data indicated that chronic exposure of AFB1 induced “gut-liver axis” injury in mice under HFD and normal diet (ND) patterns. AFB1 further aggravated hepatic and intestinal injury, and intestinal microbiota disruption in HFD mice. Bifidobacterium breve BAA-2849 intervention analysis showed that liver injury and lipid disorders caused by AFB1 exposure were alleviated by regulating the proportions of different gut microbes. We demonstrated through a mice model that the populations with a dietary pattern of HFD might be more susceptible to AFB1 exposure and adverse effects on the gut-liver axis, and the toxicity of AFB1 exposure can be alleviated by regulating the gut microbiota.