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Academic Journal
Vasodilator drugs and heart-related outcomes in systemic sclerosis: an exploratory analysis
Arsène Mekinian, Vincent Cottin, Zahir Amoura, Eric Hachulla, Yannick Allanore, David Launay, Luc Mouthon, Benjamin Chaigne, Sébastien Rivière, Olivier Fain, Brigitte Granel, Alain Lescoat, Denis Wahl, Christian Agard, Grégory Pugnet, Ariel Cohen, Emmanuel Chatelus, Bernard Bonnotte, Thomas Papo, Viviane Queyrel, Elisabeth Diot, Achille Aouba, Fabrice Carrat, Pierre Kieffer, Nadine Magy-Bertrand, Arnaud Hot, Olivier Lidove, Robin Dhote, Jean-Christophe Lega, Marie-Hélène Balquet, Jean-Emmanuel Kahn, Anne Laure Fauchais, Alain Le Quellec, Olivier Espitia, Alexis F Guedon, Jean Baptiste Gaultier
RMD Open, Vol 10, Iss 4 (2024)
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| Title | Vasodilator drugs and heart-related outcomes in systemic sclerosis: an exploratory analysis |
|---|---|
| Authors | Arsène Mekinian, Vincent Cottin, Zahir Amoura, Eric Hachulla, Yannick Allanore, David Launay, Luc Mouthon, Benjamin Chaigne, Sébastien Rivière, Olivier Fain, Brigitte Granel, Alain Lescoat, Denis Wahl, Christian Agard, Grégory Pugnet, Ariel Cohen, Emmanuel Chatelus, Bernard Bonnotte, Thomas Papo, Viviane Queyrel, Elisabeth Diot, Achille Aouba, Fabrice Carrat, Pierre Kieffer, Nadine Magy-Bertrand, Arnaud Hot, Olivier Lidove, Robin Dhote, Jean-Christophe Lega, Marie-Hélène Balquet, Jean-Emmanuel Kahn, Anne Laure Fauchais, Alain Le Quellec, Olivier Espitia, Alexis F Guedon, Jean Baptiste Gaultier |
| Publication Year |
2024
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| Source |
RMD Open, Vol 10, Iss 4 (2024)
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| Description |
Background and aims Systemic sclerosis (SSc) is an autoimmune connective disease characterised by excessive extracellular matrix deposition and widespread skin and internal organ fibrosis including various cardiac manifestations. Heart involvement is one of the leading causes of death among patients with SSc. In this study, we aimed to assess the effect of various vasodilator treatments.Methods We used data from a national multicentric prospective study using the French SSc national database. We estimated the average treatment effect (ATE) of sildenafil, bosentan, angiotensin-converting enzyme (ACE) inhibitors and iloprost on diastolic dysfunction, altered ejection fraction
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| Document Type |
article
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| Language |
English
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| Publisher Information |
BMJ Publishing Group, 2024.
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| Subject Terms | |
