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Academic Journal
Chromatographic column with nitrile sorbent USED in the analysis of hydroxycarbamide by hydrophilic interaction liquid chromatography
A. S. Osipov, E. B. Nechaeva, L. A. Truhacheva
Регуляторные исследования и экспертиза лекарственных средств, Vol 0, Iss 3, Pp 58-61 (2018)
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| Title | Chromatographic column with nitrile sorbent USED in the analysis of hydroxycarbamide by hydrophilic interaction liquid chromatography |
|---|---|
| Authors | A. S. Osipov, E. B. Nechaeva, L. A. Truhacheva |
| Publication Year |
2018
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| Source |
Регуляторные исследования и экспертиза лекарственных средств, Vol 0, Iss 3, Pp 58-61 (2018)
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| Description |
The possibility of using chromatographic columns Zorbax SB CN 150´4,6 mm (5 μm) for separation of hydroxycarbamide (hydroxyurea) and its impurity urea has been investigated. The mixture of acetonitrile and water has been used as a mobile phase used. Separation of analytes on nitrile columns under the conditions of hydrophilic interaction liquid chromatography is possible only when the content of acetonitrile in the mobile phase is more than 90 %. When performing chromatographic procedure with Zorbax SB CN on nitrile column, the change in elution order of hydroxycarbamide and urea has been detected, compared to the elution order on amino column Zorbax NH2.
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| Document Type |
article
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| Language |
Russian
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| Publisher Information |
Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’), 2018.
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| Subject Terms |
высокоэффективная жидкостная хроматография, хроматография гидрофильных взаимодействий, гидроксикарбамид (гидроксимочевина), нитрильный сорбент, фармакопея, high-performance liquid chromatography, hydrophilic interaction liquid chromatography, hydroxycarbamide (hydroxyurea), nitrile sorbent, pharmacopoeia, Medicine (General), R5-920
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