Thyroidectomy, Thyroid cancer, Thyroid nodule, Postoperative complications, Smoking, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

Abstract Objective Tobacco use has been confirmed to be a risk factor for postoperative complications, but the impact of smoking on adverse outcomes following thyroidectomy remains largely unknown. Methods Using data spanning 2016–2020 from the National Inpatient Sample, patients aged ≥ 18 years who underwent thyroidectomy for thyroid malignancy or other thyroid disorders were identified and classified into two groups: current smokers and non-smokers. We compared outcome variables between the two groups via univariate analysis and adjusted multivariate logistic regression. Results The present study included 13,737 records of patients who underwent thyroidectomy, among whom 1,360 (9.90%) were identified as current smokers. After propensity score matching, logistic regression analysis suggested that smoking was associated with a heightened risk of unfavorable discharge (aOR = 1.27, 95% CI [1.05–1.54], P = 0.012), vocal dysfunction (aOR = 1.25, 95% CI [1.00–1.55], P = 0.049), hypocalcemia (aOR = 1.23, 95% CI [1.05–1.44], P = 0.010), hypomagnesemia (aOR = 1.58, 95% CI [1.19–2.09], P = 0.001), and respiratory complications (aOR = 1.39, 95% CI [1.16–1.68], P