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Academic Journal
Response to SARS-CoV-2 initial series and additional dose vaccine in pediatric patients with predominantly antibody deficiency
Megha Tandon, Daniel V. DiGiacomo, Baijun Zhou, Paul Hesterberg, Chen E. Rosenberg, Sara Barmettler, Jocelyn R. Farmer
Frontiers in Immunology, Vol 14 (2023)
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| Title | Response to SARS-CoV-2 initial series and additional dose vaccine in pediatric patients with predominantly antibody deficiency |
|---|---|
| Authors | Megha Tandon, Daniel V. DiGiacomo, Baijun Zhou, Paul Hesterberg, Chen E. Rosenberg, Sara Barmettler, Jocelyn R. Farmer |
| Publication Year |
2023
|
| Source |
Frontiers in Immunology, Vol 14 (2023)
|
| Description |
Data regarding response to SARS-CoV-2 immunization in pediatric patients with predominantly antibody deficiency (PAD) is limited. We evaluated SARS-CoV-2 immunization response by anti-SARS-CoV-2-spike antibody level in 15 pediatric PAD patients. These data were compared to a published cohort of adult PAD patients (n=62) previously analyzed following SARS-CoV-2 immunization at our single center institution. We evaluated demographics, clinical characteristics, immunophenotype, infection history, and past medication use by chart review. Following a two-dose monovalent initial series SARS-CoV-2 immunization, mean anti-SARS-CoV-2-spike antibody levels were significantly higher in pediatric PAD patients compared to adult PAD patients (2,890.7 vs. 140.1 U/mL; p
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| Document Type |
article
|
| Language |
English
|
| Publisher Information |
Frontiers Media S.A., 2023.
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| Subject Terms | |
