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Academic Journal
The influence of the plantain juice on the manifestations and outcome of acute cyclophosphamide intoxication in rats
T. V. Schäfer, J. J. Ivnitsky, V. L. Rejniuk
Биопрепараты: Профилактика, диагностика, лечение, Vol 0, Iss 3, Pp 61-63 (2018)
Sparad:
| Titel | The influence of the plantain juice on the manifestations and outcome of acute cyclophosphamide intoxication in rats |
|---|---|
| Författarna | T. V. Schäfer, J. J. Ivnitsky, V. L. Rejniuk |
| Utgivningsår |
2018
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| Källa |
Биопрепараты: Профилактика, диагностика, лечение, Vol 0, Iss 3, Pp 61-63 (2018)
|
| Beskrivning |
To estimate the influence of the plantain juice on neurological manifestations of the severe acute cyclophosphamide intoxication, rats have been gavaged with 4 ml/kg plantain juice 1 h before cyclophosphamide dosing (intraperitoneally, 600 mg/kg). Within 3 h after cyclophosphamide administration, rats’ blood ammonia, glutamine and urea was increased. These alterations have been attenuated with the prophylactic administration of the plantain juice. At the background of the administration of the plantain juice the hypodynamia was less pronounced, duration of life has increased. Therefore, experimentally has been demonstrated the potency of the plantain juice usage for prophylaxis of hyperammonaemic and neurotoxic action of cyclophosphamide.
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| Dokumenttyp |
article
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| Språk |
Russian
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| Information om utgivare |
Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products», 2018.
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| Ämnestermer | |
