фрагментация днк, мужское бесплодие, показатели спермограммы, мужской фактор, анализ эякулята, Pediatrics, RJ1-570, Gynecology and obstetrics, RG1-991

The standard method for diagnosing male infertility involves a spermogram, which does not always give a complete picture of male fertility. One additional method for assessing ejaculate is the sperm DNA fragmentation test (SDF), which determines the integrity of the paternal genome. Objective – to study sperm DNA fragmentation in Kuzbass men and evaluate potential relationships between the level of DNA damage, clinical parameters, and spermogram parameters. Results. The results of the study demonstrate a significant statistical relationship between DNA fragmentation of spermatozoa with progressive motility (p < 0.049), age (p < 0.040) and body mass index (BMI) (p < 0.028). Also, %SDF is significantly higher in asthenozoospermic patients (p < 0.004) than in normal patients. A correlation with %SDF was observed in terms of general (r = -0.265) and progressive (r = -0.254) mobility, viability (r = -0.205), as well as clinical parameters, age (r = 0.331) and BMI (r = 0.279). Conclusions. The study found a relationship between DNA fragmentation and motility, viability of spermatozoa, age of patients and their BMI.