FX06, Vascular leakage, Endothelial hyperpermeability, Acute respiratory distress syndrome, SARS-CoV-2, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

Abstract Background Vascular leakage is a major feature of acute respiratory distress syndrome (ARDS). We aimed to evaluate the efficacy of FX06, a drug under development that stabilizes interendothelial cell junctions, at reducing vascular leakage during SARS-CoV-2-induced ARDS. Methods This multicenter, double-blinded, randomized trial included adults with COVID-19-associated ARDS who had received invasive mechanical ventilation for