новорожденные, недоношенные, критические состояния, биомаркеры, прокальцитонин, белок s100β, лабораторный мониторинг, перинатальная патология, антибактериальная терапия., Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9

Objective: to determine quantitative changes in procalcitonin (PCT) and S100β protein in serum from newborn infants under the long-term intensive care in an intensive care unit in order to optimize managing the care. Subjects and methods. A study group prospectively included 69 critically ill neonates of more than 2 days of birth admitted to the neonatal intensive care unit. The levels of PCT (normal values Results. In critically ill neonates, both biomarkers were shown to be increased in most cases. The level of PCT varied from the normal values up to 72 ng/ml [mean 1.03 (range 0.36—3.92 ng)]. Mean level of S100β protein was 0.339 (range 0.234—0.481) ^g/l. Levels of PCT and S100β positively correlated (r=0.47; p