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Academic Journal

TNF-α/NF-κB mediated upregulation of Dectin-1 in hyperglycemic obesity: implications for metabolic inflammation and diabetes

Ashraf Al Madhoun, Dania Haddad, Shihab Kochumon, Reeby Thomas, Lavina Miranda, Preethi George, Nermeen Abu-Khalaf, Fahd Al-Mulla, Rasheed Ahmad

Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-14 (2025)

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Bibliografiska uppgifter
Titel TNF-α/NF-κB mediated upregulation of Dectin-1 in hyperglycemic obesity: implications for metabolic inflammation and diabetes
Författarna Ashraf Al Madhoun, Dania Haddad, Shihab Kochumon, Reeby Thomas, Lavina Miranda, Preethi George, Nermeen Abu-Khalaf, Fahd Al-Mulla, Rasheed Ahmad
Utgivningsår
2025
Källa
Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-14 (2025)
Beskrivning
Abstract Background Dectin-1, a key innate immune receptor, plays a critical role in cellular responses and is implicated in chronic inflammation and metabolic syndromes. This study addresses a pivotal gap in elucidating the regulatory mechanism governing Dectin-1 expressionin obesity and diabetes, hypothesizing that hyperglycemia and TNF-α synergistically upregulate Dectin-1 in adipose tissue (AT), thereby exacerbating inflammatory responses and contributing to metabolic dysfunction. Methods The study included 95 overweight and obese Kuwaiti individuals, categorized into prediabetic (HbA1c
Dokumenttyp
article
Språk
English
Information om utgivare
BMC, 2025.
Ämnestermer
Dectin-1, AT, TNF-α, NF-κB, HbA1c, Diabetes, Medicine
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