Регуляторные исследования и экспертиза лекарственных средств, Vol 0, Iss 1, Pp 16-20 (2018)

Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’), 2018.

невралгия тройничного нерва, терапевтический лекарственный мониторинг, антиконвульсант, персонализированная медицина, рациональная фармакотерапия, trigeminal neuralgia, therapeutic drug monitoring, anticonvulsant, personalized medicine, rational pharmacotherapy, Medicine (General), R5-920

Optimization of pharmacotherapy (selection of optimal doses and dosing intervals) is a major objective of clinical pharmacology. This objective may be achieved, in part, by implementation of modern pharmacokinetic approaches and the use of therapeutic drug monitoring that consists in selection of an appropriate dose level and dosing interval based on information about drug concentrations at certain timepoints. This is particularly important for drugs with a narrow therapeutic range. The authors of the article advocate the usefulness of therapeutic drug monitoring in treating exacerbation of trigeminal neuralgia with carbamazepin and evaluate practical relevance of development of a new phenotyping method that could be used to increase pharmacotherapy efficiency and safety.