Laddar…
Academic Journal
Associations of DNA Methylation Algorithms of Aging With Cardiovascular Disease and Mortality Risk Among US Older Adults
Xian Cui, Shiqun Sun, Hui Zhang, Yulu Gong, Darong Hao, Yaqian Xu, Chongyu Ding, Jing Wang, Tongyan An, Jinlong Liu, Jun Du, Xiangwei Li
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 14, Iss 9 (2025)
Sparad:
| Titel | Associations of DNA Methylation Algorithms of Aging With Cardiovascular Disease and Mortality Risk Among US Older Adults |
|---|---|
| Författarna | Xian Cui, Shiqun Sun, Hui Zhang, Yulu Gong, Darong Hao, Yaqian Xu, Chongyu Ding, Jing Wang, Tongyan An, Jinlong Liu, Jun Du, Xiangwei Li |
| Utgivningsår |
2025
|
| Källa |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 14, Iss 9 (2025)
|
| Beskrivning |
Background Several DNA methylation (DNAm) algorithms have recently emerged as robust predictors of aging and adverse health outcomes in older adults, offering valuable insights into cardiovascular disease (CVD) risk stratification. However, their predictive performance for CVD varies significantly. This study aimed to systematically investigate the associations of 12 widely used DNAm algorithms with CVD and mortality risk. Methods Data from the NHANES (National Health and Nutrition Examination Survey) 1999 to 2002 were used to assess 12 DNAm algorithms (eg, HannumAgeacc, PhenoAgeacc, GrimAgeMortacc, GrimAge2Mortacc) in relation to CVD risk and mortality. Two cohorts were analyzed: one for CVD risk (n=1230) and another for CVD mortality risk (n=1606). DNAm was measured using the Infinium Methylation EPIC BeadChip kit (Illumina). Odds ratios (ORs) and hazard ratios (HRs), along with 95% CIs per SD increase of these DNAm algorithms, were calculated. Results Significant associations were observed for GrimAgeMortacc and GrimAge2Mortacc with coronary heart disease and heart attack, with multivariable‐adjusted ORs per SD increase ranging from 2.15 to 2.76. However, several algorithms exhibited no significant association with self‐reported prevalent CVD. For mortality risk, HannumAgeacc, PhenoAgeacc, ZhangAgeacc, GrimAgeMortacc, and GrimAge2Mortacc were significantly associated with CVD mortality. The multivariable‐adjusted HRs per SD increase were 1.19 (95% CIs, 1.05–1.34), 1.13 (95% CIs, 1.01–1.26), 1.63 (95% CI, 1.08–2.47), 1.90 (95% CIs, 1.51–2.40), and 1.87 (95% CIs, 1.51–2.32), respectively. These associations were consistent across biological sex, age (≥50 and
|
| Dokumenttyp |
article
|
| Språk |
English
|
| Information om utgivare |
Wiley, 2025.
|
| Ämnestermer | |
