пирогенал, бактериальный липополисахарид, пиротерапия, история психиатрии, терапевтическая резистентность, депрессивные состояния, маниакальные состояния, шизофрения, алкоголизм, наркомания, нейродегенеративные заболевания, черепно-мозговые травмы, нейрос, Agriculture, Science

Purpose. To make a thorough historical review about the use of pyrotherapy with bacterial LPS (including Pyrogenal) in Soviet, post-Soviet and Western psychiatry, and to show its therapeutic utility, to reach an objective conclusion on its use and value, and to present two treatment-resistant clinical cases in which remission was obtained only after Pyrogenal use, while all other biological methods tried, together with standard psychopharmacotherapy, have failed in these cases. Methodology. We have performed a deep historical literature search in the libraries of Tel-Aviv University, Medical Faculty, and Stavropol State Medical University, and in PubMed. The data we have found regarding Pyrogenal and bacterial LPS therapeutic use, are then presented there. Together with such historical data, we also present and describe two clinical cases we have met in our practice. Results. Results we have obtained by this historical review and review of the cases presented, definitely show that pyrotherapy (including therapy with bacterial LPS and Pyrogenal in particular) is still an useful therapeutic method of overcoming treatment resistance. Practical implications. Our results can be applied in psychiatry, substance use medicine and neurology, especially in treatment-resistant subpopulations.