Chronic periodontitis and odontogenic subcutaneous granuloma of the face: remarks by immunologic parallels

2020

Эндодонтия Today, Vol 15, Iss 1, Pp 8-12 (2020)

To clarify the formation mechanisms of immune dysfunction leading to the development of odontogenic subcutaneous granuloma person (OPG) in patients with chronic foci stomatogennoy infection were examined 54 patients aged 18 to 45 years suffering from chronic granulomatous periodontitis (present study included), of which 19 were diagnosed - OPGL and 30 patients in the comparison group of the same age who have studied the content in the saliva of proinflammatory (interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), of tumor necrosis factor-α (TNFa)) and antiinflammatory (interleukin receptor antagonist-1 (RAIL), interleukin-4 (IL-4), interleukin-10 (IL-10)) cytokines by enzyme immunoassay. It is shown that the development of inflammation in the present study included OPGL is characterized by the strengthening of the immune system and increased levels in the saliva of proinflammatory cytokines. Made a preliminary conclusion that a violation of the process of inflammation with a predominance of the synthesis of anti-inflammatory cytokines, such as IL-10 may lead to the development of smoldering inflammation in subcutaneous adipose tissue of the face and the appearance of OPGL.

article

Russian

LLC "Endo Press", 2020.

хронический периодонтит, одонтогенная подкожная гранулема лица, хронические одонтогенные очаги периапикальной и пародонтальной инфекции, пародонтит, эндодонтическое лечение, местный иммунитет, chronic periodontitis, odontogenic subcutaneous granuloma of face chronic odontogenic lesions, periodontitis, endodontic treatment, local immunity, Dentistry, RK1-715