ротовая жидкость, антиоксидантная система, окислительный стресс, oral fluid, antioxidant system, oxidative stress, Medicine

The article presents the results of studies of metabolic indicators of oral liquid in patients with a wide range of somatic illnesses that reflecting the functional state of the prooxidant-antioxidant system. During the studies established that most increase in activity of oxidation processes in the background of decrease in activity of all enzymes of antiradical protection was observed in patients with diabetes mellitus type 2. Also a significant increase in FRO was observed in patients with chronic obstructive pulmonary disease, while they have identified imbalance in the functioning of enzyme systems and the highest amplitude changes in the activity of enzymes of antiradical protection. We also established the activation of free radical processes in patients of other groups, but less pronounced on the background of a minor changes in the activity of enzymes. The obtained data demonstrate the development of oxidative stress at the local level in the oral fluid which is probably a reflection of the systemic metabolic changes under examined somatic pathologies and presents prospect of studying oral fluid in the laboratory diagnosis of oxidative metabolism disorders.