Internal combustion (IC) engines serve as power devices that are widely applied in the fields of transport, engineering machinery, stationary power generation, etc., and are evolving towards the goal of higher efficiency and lower environmental impacts. In this Editorial, the role of IC engines for future transport and energy systems is discussed, and research directions for advancing IC engine and fuel technologies are recommended. Finally, we introduce the 14 technical papers collected for this Special Issue, which cover a wide range of research topics, including diesel spray characteristics, combustion technologies for low- and zero-carbon fuels, advanced combustion mode, fuel additive effects, engine operation under extreme conditions and advanced materials and manufacturing processes.