biliopancreatoduodenal zone tumors, periampulary tumors, mechanical jaundice, endotoxemia, percutaneous transhepatic cholangiostomy, interleukin-6, bilesorption, Surgery, RD1-811

The OBJECTIVE was to study changes of IL-6 concentration in the blood and bile in patients with MJ of tumor genesis by means of biliary sorption.METHODS AND MATERIALS. The investigation was conducted to study changes in the concentration of IL-6 in the blood and bile against the background of bile sorption in 105 patients with mechanical jaundice (MJ), the cause of obturation was a tumor of the periampullary zone. The patients are divided into two groups. The first group consisted of 51 patients, the second group included 54 patients. All patients of the main group underwent percutaneous perhepatic cholangiostomy for the purpose of decompression; bile sorption was performed using the domestic Lignov enterosorbent. The level of IL-6 in blood serum and bile was determined by enzyme immunoassay.RESULTS. The use of bile sorption in the treatment complex significantly changed the concentration of IL-6 in blood serum (P