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Academic Journal
Genetic polymorphisms and effecacy of antivital therapy ofchronic viral hepatitis C
L I Nikolaeva, Е I Sамоkhvalov, S V Al'khovskiy, A V Kolotvin, L М Samokhodskaya, V V Makashova, A К Тokmalaev
RUDN Journal of Medicine, Vol 0, Iss 2, Pp 81-88 (2012)
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| Title | Genetic polymorphisms and effecacy of antivital therapy ofchronic viral hepatitis C |
|---|---|
| Authors | L I Nikolaeva, Е I Sамоkhvalov, S V Al'khovskiy, A V Kolotvin, L М Samokhodskaya, V V Makashova, A К Тokmalaev |
| Publication Year |
2012
|
| Source |
RUDN Journal of Medicine, Vol 0, Iss 2, Pp 81-88 (2012)
|
| Description |
Aim: to determine influence of genetic polymorphisms of hepatitis C virus and single nucleotide polymorphisms (SNPs) of patients with chronic hepatitis C on achieving sustained virological response (SVR) to antiviral therapy. One hundred blood samples of eastern-Slavonic patients with different response to the therapy were analyzed. It was determined, that among SNPs of 7 human genes only allelic variants of IL-1β, IL-28B, TGF-β1 and viral genotypes can influence on probability to achieve SVR.
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| Document Type |
article
|
| Language |
English
Russian |
| Publisher Information |
Peoples’ Friendship University of Russia (RUDN University), 2012.
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| Subject Terms | |
