rotational atherectomy, calcific coronary lesion, quantitative flow ratio, ultrasonic flow ratio, major adverse coronary events, Diseases of the circulatory (Cardiovascular) system, RC666-701

IntroductionThe potential role of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) and ultrasonic flow ratio (UFR) in predicting adverse outcomes in patients with successful rotational atherectomy (RA) and stent placement remains to be defined.MethodsA total of 68 patients with highly calcific lesions, who underwent both QFR and UFR measurements after PCI with both RA and stenting, were enrolled. The major adverse coronary events (MACE) of 62 patients who completed 12-month follow-up were analyzed. The clinical characteristics of 9 patients with MACE and 53 non-MACE patients were compared. The predictors of MACE were analyzed using LASSO regression combined with Cox regression analyses.ResultsPatients with MACE had more lipid-rich and mixed plaques, less stent expansion and symmetry index, and lower post-PCI QFR and UFR compared with non-MACE patients. Cox regression analyses found that patients with lower post-PCI QFR (P